A través de códigoF, la publicación Science/AAAS Custom Publishing Office invita a todas las personas interesadas en el tema o área de especialidad al seminario web “Deciphering aging: Linking senescence with DNA damage and the cell cycle”, en el que los participantes tendrán la oportunidad de ver y escuchar las presentaciones de:

Sheila A. Stewart, Ph.D. Washington University in St. Louis St. Louis, MO.

Dr. Stewart is a professor in the Department of Cell Biology and Physiology at Washington University School of Medicine in St. Louis and associate director for Basic Science at the Siteman Cancer Center. She received her Ph.D. in microbiology and immunology from the University of California, Los Angeles in 1997, and completed her postdoctoral fellowship in cancer biology at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology in Robert Weinberg’s laboratory. She is also an American Cancer Society Research Scholar. Dr. Stewart’s research is focused on understanding how age-related changes in the tumor microenvironment impact tumorigenesis. Her laboratory has shown that aged stromal cells, like cancer-associated fibroblasts, express a plethora of protumorigenic factors, and has developed murine models to explore the role of senescent stromal cells in tumorigenesis. A recent focus of the laboratory is examining how age-related changes in the premetastatic niche facilitate tumor cell seeding, dormancy, and outgrowth in the bone, and how these changes alter the local immune response to facilitate tumor cell proliferation.

James L. Kirkland, M.D., Ph.D. Mayo Clinic Rochester, MN.

Dr. Kirkland is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism, director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic, and the Noaber Foundation Professor of Aging Research. His research covers cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities. He published the first article about drugs that clear senescent cells, known as senolytic agents. He is a scientific advisory board member for several companies and academic organizations and a member of the National Advisory Council on Aging of the U.S. National Institutes of Health, as well as president-elect of the American Federation for Aging Research and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands.

Sean Sanders, Ph.D. Science/AAAS, Washington, DC.

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently Dr. Sanders is the Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

Sobre el tema del webinario, Science AAA, comenta: “La senescencia describe la compleja respuesta celular al estrés, lo que incluye la detención irreversible del ciclo celular y por lo tanto la prevención de la proliferación de células defectuosas o dañadas. Este efecto hace que la senescencia sea un componente clave en la respuesta de la supresión tumoral del cuerpo y la inicialización de las vías de reparación, proporcionando un mecanismo de promoción de la salud. Por el contrario, las células senescentes pueden acumularse en los tejidos afectados de personas con enfermedades relacionadas con la edad, como demencias, artritis, aterosclerosis y otras; dicha acumulación se considera un sello distintivo del envejecimiento que conduce a muchas patologías relacionadas con la edad. Estas funciones aparentemente contradictorias hacen de la senescencia celular un objetivo de investigación interesante para desarrollar terapias de supresión del cáncer, así como para mejorar el mantenimiento de la salud y extender la vida humana”.

El seminario web se llevará a cabo el miércoles 19 de septiembre, con una duración de 90 minutos.

Deciphering aging: Linking senescence with DNA damage and the cell cycle

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Horario: 12 horas del este, 9 a.m. Pacífico, 5 p.m. Reino Unido (BST),
a las 6 p.m. Europa Central (CEST)

Informes e inscripciones